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Wolberger Lab

Welcome to the laboratory of Cynthia Wolberger, located in the Department of Biophysics and Biophysical Chemistry. Our research is focused on the structural and mechanistic basis of transcriptional regulation and ubiquitin signaling. We use a combination of cryo-EM, x-ray crystallography, and a variety of biophysical and biochemical approaches to gain insights into the fundamental mechanisms underlying these processes. Please follow the links on this page to learn more about our research and lab members.

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Recent News

Congratulations to our newest Ph.D., Chad Hicks!

Congratulations to our newest Ph.D., Chad Hicks!

Congratulations to Dr. Chad Hicks, who gave his thesis seminar on Feb. 23. We are all very proud of you. Good luck in the next phase of your career!

News
Sanim Rahman awarded an F31 fellowship

Sanim Rahman awarded an F31 fellowship

Congratulations to PMB student, Sanim Rahman, who has received an F31 fellowship from NCI!

News
Welcome James Fields, new postdoc!

Welcome James Fields, new postdoc!

We welcome postdoctoral fellow, James Fields,  to the Wolberger lab! James did his Ph.D. research with Eric Sundberg at the University of Maryland School of Maryland. Welcome, James!

New Lab Member

Lab Info

Prospective graduate students…

should visit the following web sites:


Interested in a postdoctoral position?

Please see the Join Our Team page for information.


Looking for a plasmid?

Many of our plasmids are available through Addgene. View the list of available plasmids.

Our Research

Selected Recent Publications

Hicks CW, Rahman S, Gloor SL, Fields JK, Husby NL, Aup Vaidya A, Maier KE, Morgan M, Keogh MC, Wolberger C. (2024) Ubiquitinated histone H2B as gatekeeper of the nucleosome acidic patch. bioRxiv 2024.02.22.581437.

Zhao F, Hicks CW, Wolberger C (2023) Mechanism of histone H2B monoubiquitination by Bre1 (2023) Nat Struct Mol Biol. 30(11):1623-1627. doi: 10.1038/s41594-023-01137-x.

Rahman S, Hoffmann NA, Worden EJ, Smith ML, Namitz KEW, Knutson BA, Cosgrove MS, Wolberger C. (2022) Multistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome. Proc Natl Acad Sci U S A. 20;119(38):e220569111. doi: 10.1073/pnas.2205691119

Lombardi PM, Haile S, Rusanov T, Rodell R, Anoh R, Baer JG, Burke KA, Gray LN, Hacker AR, Kebreau KR, Ngandu CK, Orland HA, Osei-Asante E, Schmelyun DP, Shorb DE, Syed SH, Veilleux JM, Majumdar A, Mosammaparast N, Wolberger C. (2022) The ASCC2 CUE domain in the ALKBH3-ASCC DNA repair complex recognizes adjacent ubiquitins in K63-linked polyubiquitin. J Biol Chem. 28:101545. doi: 10.1016/j.jbc.2021.101545.

Morgan MT, Ikenoue T, Suga H, Wolberger C. (2022) Potent macrocycle inhibitors of the human SAGA deubiquitinating module. Cell Chem Biol 29(4):544-554.e4 doi: 10.1016/j.chembiol.2021.12.004